Human Streptococcus pneumoniae antibodies and uses therefor
AssigneeOklahoma Medical Research Foundation
InventorKenneth Smith
Life of this patent
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Abstract
The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies.
Claims13
A panel comprising two or more serotype-specific antibodies or binding fragments thereof that bind to Streptococcus pneumoniae or bind to antigens of S. pneumoniae immobilized on a solid support, wherein the two or more serotype-specific antibodies or binding fragments thereof comprise:
- a heavy chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth in SEQ ID NOS:
- 253 to 257, 269, 294 to 304, 331 to 337, 351 to 354, or 360 to 364;
- and
- a light chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth SEQ ID NOS:
- 286, 313 to 323, 344 to 350, 365 to 368, or 374 to 378.
A kit for the detection of Streptococcus pneumoniae comprising a panel comprising one or more serotype-specific antibodies or binding fragments thereof that bind to Streptococcus pneumoniae or bind to antigens of S. pneumoniae immobilized on a solid support, a suitable container, and optionally an immunodetection reagent, wherein the antibodies or binding fragments thereof comprise:
- a heavy chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth in SEQ ID NOS:
- 253 to 257, 269, 294 to 304, 331 to 337, 351 to 354, or 360 to 364;
- and
- a light chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth SEQ ID NOS:
- 286, 313 to 323, 344 to 350, 365 to 368, or 374 to 378,
- wherein the panel includes antibodies or binding fragments thereof selected to bind to S. pneumoniae serotypes 1, 2, 3, 4, 5, 6B, 8, 9N, 9V, 11B, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F, and CWPS.
Dependencies are inferred from the claim text.