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US 12,352,673 B2Granted
Manipulation of microfluidic droplets
AssigneeBio-Rad Laboratories, Inc.
InventorsBenjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
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Abstract
The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
Claims17
A feedback control system for microfluidic droplet manipulation, the system comprising:
- at least one pump operable to pump a sample fluid from the pump through an inlet channel and into a junction with a main channel on a microfluidic device, thereby to cause the system to form microfluidic droplets of the sample fluid surrounded by a carrier fluid at the junction;
- a flow rate sensor operable to measure a flow rate to the inlet channel;
- and
- a feedback controller operable to receive a flow rate measurement from the flow rate sensor and adjust a flow rate of the at least one pump to cause the system to form the microfluidic droplets at a uniform size.
1 more element
Dependencies are inferred from the claim text.