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US 12,351,851 B2Granted
Disruption of CDC42 effectors in yeast for increased alcohol and lysine production
AssigneeDanisco US Inc.
InventorsJaclyn Diana Demartini, Celia Emily Gaby Payen
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Abstract
Described are compositions and methods relating to yeast having a genetic mutation that results in decreased amounts of Cdc42 effector proteins, resulting in increased alcohol and lysine production. Such yeast is well-suited for use commercial alcohol production to increase yields and to increase the value of Such yeast is well-suited for use commercial alcohol production to increase yields and to increase the value of amino-acid-containing, fermentation-co-products.
Claims13
Modified yeast cells derived from parental yeast cells, the modified yeast cells comprising:
- (a) a genetic alteration that causes the modified yeast cells to produce a decreased amount of functional Cdc42 effector polypeptides compared to the parental yeast cells, wherein the genetic alteration comprises a disruption of a YHR061c gene, or homolog, thereof, encoding a Gic1 polypeptide and/or disruption of a YDR309c gene, or homolog, thereof, encoding a Gic2 polypeptide, present in the parental yeast cells;
- and
- (b) an exogenous gene encoding a carbohydrate processing enzyme;
- wherein the modified yeast cells demonstrate increased alcohol production and/or increased lysine production compared to the parental yeast cells under equivalent fermentation conditions.
1 more element
Dependencies are inferred from the claim text.