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US 12,351,843 B2Granted
Method for purifying and quantifying thrombin and its degradation polypeptides
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsTamar Auerbach-Nevo, Nadav Orr, Israel Nur
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Abstract
Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.
Claims4
A solution comprising:
- homogenous post-translationally modified α-thrombin, and an eluent comprising a mixture of amines, wherein the isolated homogenous post-translationally modified α-thrombin is homogeneously sialylated α-thrombin.
Dependencies are inferred from the claim text.