Soluble antibody complexes for T cell or NK cell activation and expansion
AssigneeStemcell Technologies Canada Inc.
InventorAndy Isamu Kokaji
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Abstract
This disclosure provides compositions and methods for the activation and expansion of human T cells or NK cells using soluble monospecific antibody complexes.
Claims12
A method of activating human NK cells comprising culturing a sample containing human NK cells with a composition comprising at least one soluble monospecific complex, wherein each soluble monospecific complex comprises two antibodies or F(ab′)2 fragments thereof which are linked and bind to the same antigen on the human NK cells,
- wherein the at least one soluble monospecific complex comprises two anti-CD335 antibodies or F(ab′)2 fragments thereof that bind a CD335 antigen on the human NK cells.
A method of activating human NK cells comprising culturing a sample containing human NK cells with a composition comprising at least two soluble monospecific complexes, wherein each soluble monospecific complex comprises two antibodies or F(ab′)2 fragments thereof which are linked and bind to the same antigen on the human NK cells,
- wherein a first soluble monospecific complex of the composition comprises two anti-CD335 antibodies or F(ab′)2 fragments thereof that bind a CD335 antigen on the human NK, cells, and
- wherein the composition further comprises a second soluble monospecific complex comprising two anti-CD2 antibodies or F(ab′)2 fragments thereof that bind a CD2 antigen on the human NK cells.
Dependencies are inferred from the claim text.