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US 12,351,821 B2Granted
Method to prepare sperm
AssigneeUniversity of Massachusetts
InventorsPablo E. Visconti, Felipe Navarrete
Life of this patent
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Abstract
Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and/or extending the lifespan of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore are provided. Such methods may be used in, for example, artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.
Claims16
A method to increase fertility comprising
- a) isolating biological fluid comprising sperm;
- b) removing energy nutrients from said biological fluid in a);
- c) placing said sperm of a) and/or b) in a media absent energy nutrients for a period of time;
- d) adding an energy nutrient to said media and/or sperm of c);
- and
- e) contacting or injecting said sperm from d) with an ovum of the same species as the sperm, so as to increase fertility as compared to a method where sperm cells have not undergone energy nutrient starvation.
3 more elements
Dependencies are inferred from the claim text.