Recombinant oncolytic virus

A recombinant viral vector comprising a nucleic acid encoding a Second Mitochondria-derived Activator of Caspases (SMAC) protein inserted within the genome of a vesicular stomatitis virus (VSV),

• wherein the SMAC protein consists of the amino acid sequence SEQ ID NO:1 or 2, or a conservative variant thereof having an IAP-binding motif comprising the amino acid sequence SEQ ID NO:3 and that specifically binds to at least a portion of an Inhibitor of Apoptosis Protein (IAP),
• wherein the virus genome comprises at least a nucleoprotein (N or NP) gene, a phosphoprotein (P) gene, a glycoprotein (G) gene, and a matrix protein (M) gene,
• wherein the G gene encodes a modified G protein that consists of the amino acid sequence SEQ ID NO:5 with a peptide sequence six amino acids or less comprising an RGD sequence inserted after amino acid position 190 of SEQ ID NO:5, and
• wherein the nucleic acid encoding SMAC protein is inserted between the M gene and glycoprotein (G) gene.