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US 12,351,780 B2Granted
Peptide acetals for stabilising enzymes
AssigneeBASF SE
InventorsAllan F. Cunningham, Stefan Jenewein, Gabriele Boenemann
Life of this patent
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Abstract
The present invention relates to a compound for stabilizing enzymes, the use of said compound for stabilizing an enzyme, a composition comprising said compound, a method of preparing the composition comprising said compound, a detergent composition comprising said compound and a method of preparing said compound.
Claims19
A compound of formula (I) or a salt thereof
- wherein:
- R1 is a group such that NH—CHR1—CO is an L or D-amino acid residue of Gly or Val, R2 is a group such that NH—CHR2—CO is an L or D-amino acid residue of Ala, and R3 is a group such that NH—CHR3—CO is an L or D-amino acid residue of Tyr, Ala, or Leu;
- R4 and R5 are each independently selected from the group consisting of hydrogen, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C1-8 alkoxy, optionally substituted C1-4 acyl, optionally substituted C1-8 alkyl phenyl, and optionally substituted 6- to 10-membered aryl;
- or wherein R4 and R5 are joined to form an optionally substituted 5- to 12-membered ring;
- and
- Z is selected from hydrogen, an N-terminal protection group, or one or more amino acid residues optionally comprising an N-terminal protection group.
3 more elements
A compound selected from:
- Cbz-Gly-Ala-Val-(OMe)2,
- Cbz-Gly-Ala-Val-(OEt)2,
- Ac-Gly-Ala-Val-(OMe)2,
- Ac-Gly-Ala-Val-(OEt)2,
- Cbz-Gly-Ala-Val-(OiPr)2,
- Cbz-Gly-Ala-Val-(OiBu)2,
- Ac-Gly-Ala-Val-(OiPr)2,
- Ac-Gly-Ala-Val-(OiBu)2,
- Bz-Gly-Ala-Val-(OMe)2,
- Bz-Gly-Ala-Val-(OEt)2,
- Fmoc-Gly-Ala-Val-(OMe)2,
- Fmoc-Gly-Ala-Val-(OEt)2,
- Bz-Gly-Ala-Val-(OiPr)2,
- Bz-Gly-Ala-Val-(OiBu)2,
- Fmoc-Gly-Ala-Val-(OiPr)2, or
- Fmoc-Gly-Ala-Val-(OiBu)2,
- wherein Cbz is benzyloxycarbonyl, Ac is acetyl, Bz is benzyl, and Fmoc is fluorenylmethyloxycarbonyl.
14 more elements
A compound selected from:
- Cbz-Val-Ala-Norvaline-(OMe)2,
- Cbz-Val-Ala-Norvaline-(OEt)2,
- Ac-Val-Ala-Norvaline-(OMe)2,
- Ac-Val-Ala-Norvaline-(OEt)2,
- Cbz-Val-Ala-Norvaline-(OiPr)2,
- Cbz-Val-Ala-Norvaline-(OiBu)2,
- Ac-Val-Ala-Norvaline-(OiPr)2,
- Ac-Val-Ala-Norvaline-(OiBu)2,
- Bz-Val-Ala-Norvaline-(OMe)2,
- Bz-Val-Ala-Norvaline-(OEt)2,
- Fmoc-Val-Ala-Norvaline-(OMe)2,
- Fmoc-Val-Ala-Norvaline-(OEt)2,
- Bz-Val-Ala-Norvaline-(OiPr)2,
- Bz-Val-Ala-Norvaline-(OiBu)2,
- Fmoc-Val-Ala-Norvaline-(OiPr)2, or
- Fmoc-Val-Ala-Norvaline-(OiBu)2,
- wherein Cbz is benzyloxycarbonyl, Ac is acetyl, Bz is benzyl, and Fmoc is fluorenylmethyloxycarbonyl.
14 more elements
A compound selected from:
- Cbz-Val-Ala-Trimethylsilyl-Ala-(OMe)2,
- Cbz-Val-Ala-Trimethylsilyl-Ala-(OEt)2,
- Ac-Val-Ala-Trimethylsilyl-Ala-(OMe)2,
- Ac-Val-Ala-Trimethylsilyl-Ala-(OEt)2,
- Cbz-Val-Ala-Trimethylsilyl-Ala-(OiPr)2,
- Cbz-Val-Ala-Trimethylsilyl-Ala-(OiBu)2,
- Ac-Val-Ala-Trimethylsilyl-Ala-(OiPr)2,
- Ac-Val-Ala-Trimethylsilyl-Ala-(OiBu)2,
- Bz-Val-Ala-Trimethylsilyl-Ala-(OMe)2,
- Bz-Val-Ala-Trimethylsilyl-Ala-(OEt)2,
- Fmoc-Val-Ala-Trimethylsilyl-Ala-(OMe)2,
- Fmoc-Val-Ala-Trimethylsilyl-Ala-(OEt)2,
- Bz-Val-Ala-Trimethylsilyl-Ala-(OiPr)2,
- Bz-Val-Ala-Trimethylsilyl-Ala-(OiBu)2,
- Fmoc-Val-Ala-Trimethylsilyl-Ala-(OiPr)2,
- Fmoc-Val-Ala-Trimethylsilyl-Ala-(OiBu)2,
- Cbz-Val-Ala-Cyclohexyl-Ala-(OMe)2,
- Cbz-Val-Ala-Cyclohexyl-Ala-(OEt)2,
- Ac-Val-Ala-Cyclohexyl-Ala-(OMe)2,
- Ac-Val-Ala-Cyclohexyl-Ala-(OEt)2,
- Cbz-Val-Ala-Cyclohexyl-Ala-(OiPr)2,
- Cbz-Val-Ala-Cyclohexyl-Ala-(OiBu)2,
- Ac-Val-Ala-Cyclohexyl-Ala-(OiPr)2,
- Ac-Val-Ala-Cyclohexyl-Ala-(OiBu)2,
- Bz-Val-Ala-Cyclohexyl-Ala-(OMe)2,
- Bz-Val-Ala-Cyclohexyl-Ala-(OEt)2,
- Fmoc-Val-Ala-Cyclohexyl-Ala-(OMe)2,
- Fmoc-Val-Ala-Cyclohexyl-Ala-(OEt)2,
- Bz-Val-Ala-Cyclohexyl-Ala-(OiPr)2,
- Bz-Val-Ala-Cyclohexyl-Ala-(OiBu)2,
- Fmoc-Val-Ala-Cyclohexyl-Ala-(OiPr)2, or
- Fmoc-Val-Ala-Cyclohexyl-Ala-(OiBu)2,
- wherein Cbz is benzyloxycarbonyl, Ac is acetyl, Bz is benzyl, and Fmoc is fluorenylmethyloxycarbonyl.
30 more elements
Dependencies are inferred from the claim text.