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US 12,351,597 B2Granted
Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of FimH
AssigneesGlaxoSmithKline Intellectual Property Development Limited, Fimbrion Therapeutics, Inc.
InventorsMichael Joseph Bishop, James Walter Janetka, Laurel Kathryn McGrane, Katherine Louisa Widdowson
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Abstract
Disclosed herein are new O-biphenyl- and O-phenylheteroarylmannoside compounds and compositions and their application as pharmaceuticals for use in the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment of diseases such as urinary tract infection.
Claims7
A compound of formula I, or a pharmaceutically acceptable salt thereof,
- in which
- Z is
- wherein:
- X is CH3, Cl, or CF3;
- Y is H or F;
- and
- each R1, R2, R3, R12, R13, R14, R15, R16, R17, R22, R23, and R24 are independently selected from the group consisting of hydrogen, CN, F, C3-6cycloalkyl, C1-6alkyl, —N(C1-6alkyl)2, —OC1-6alkyl, CF3, and
4 more elements
Dependencies are inferred from the claim text.