Metformin complexes with transition metals and P group elements
AssigneeUniversidad Santiago De Cali
InventorsRichard Fernando Dvries Arturo, Octavio Piñeros, Stephanny Villamizar Delgado
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Abstract
Disclosed herein is an invention that refers to hydrochloride metformin complexes with transition metals and group P elements, such as cobalt (II), nickel (II), copper (II), zinc (III), iron (II), bismuth (III) and their preparation method. Additionally, the present invention offers crystalline forms of the metformin-cobalt (II) complex, metformin-nickel complex and metformin-copper complex as well as methods for therapeutic use in patient treatment and their preparation method.
Claims4
A metformin-copper complex, wherein the metformin-copper complex is in a crystalline form characterized by a powder X-ray diffraction pattern comprising the following 2⊖ values:
- 9.65;
- 11.78;
- 14.05;
- 15.31;
- 16.42;
- 18.79;
- 18.90;
- 19.37;
- 20.31;
- 21.40;
- 23.15;
- 23.49;
- 23.82;
- 24.33;
- 24.80;
- 24.92;
- 25.25;
- 26.03;
- 26.82;
- 28.22;
- 29.07;
- 29.22;
- 30.33;
- 30.68;
- 31.48;
- 31.81;
- 32.00;
- 32.08;
- 33.02;
- 33.19;
- 33.61;
- 33.94;
- 34.59;
- 35.73;
- 36.04;
- 36.42;
- 36.72;
- 36.89;
- 37.07;
- 37.95;
- 38.21;
- 38.33;
- 38.58;
- 38.91;
- 39.19;
- 39.39;
- 40.54;
- 40.64;
- 40.80;
- 40.95;
- 41.30;
- 41.57;
- 41.79;
- 42.39;
- 42.86;
- 43.05;
- 43.23;
- 43.41;
- 43.59;
- 44.10;
- 44.23;
- 44.78;
- 45.10;
- 45.27;
- 45.86;
- 46.07;
- 46.94;
- 47.14;
- 47.33;
- 47.54;
- 48.02;
- 48.20;
- 48.45;
- 48.63;
- 48.84;
- 49.12;
- 49.52;
- and 49.72.
Dependencies are inferred from the claim text.