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US 12,351,578 B2Granted
Compounds for inhibiting NLRP3 and uses thereof
AssigneeVentus Therapeutics U.S., Inc.
InventorsStéphane Dorich, Miguel St-Onge
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Abstract
The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):
Claims20
A method of treating a disease, condition, or disorder comprising administering to a human subject in need thereof a compound of Formula (II-h):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is
- Y is phenyl independently substituted with one, two, or three substituents selected from the group consisting of C1-C6 haloalkyl, halo, and —R4OR5;
- R2a is hydrogen;
- R4 is a bond;
- and
- R5 is hydrogen;
- wherein treating is alleviation of an established symptom of said disease, condition or disorder in said human subject, and
- wherein said disease, condition or disorder is selected from the group consisting of a liver disease, a kidney disease, and a cardiovascular disease.
7 more elements
The method according to claim to 9, wherein the disease, condition or disorder is a kidney disease.
Dependencies are inferred from the claim text.