Aromatic compound and preparation method therefor and use thereof
AssigneeShanghai Zhigen Pharmaceutical & Technology Co., Ltd.
InventorsTao Xue, Jing Huang, Wenke Wang, Yilang Chen
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Abstract
The present invention relates to an aromatic compound and a preparation method therefor and the use thereof. Specifically, disclosed are a compound as shown in the following general formula (I), or a tautomer, an enantiomer, a diastereomer or a racemate thereof or a mixture thereof, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for preparing the above compound and the use of same in the treatment of nervous system diseases.
Claims14
A compound represented by the following general formula (I), or a tautomer, an enantiomer, a diastereomer, a racemate or a mixture thereof, or a pharmaceutically acceptable salt thereof;
- wherein,
- A is CH2;
- N1 is 1 and N2 is 0, 1, 2, 3 or 4;
- R1 and R2 are each independently hydrogen, or C1-C6 alkyl, and the above-mentioned alkyl can be independently substituted by 1 to 2 substituents selected from the group consisting of halogen, hydroxyl, amino, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, and C1-C4 haloalkoxy;
- R3 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy or halogen;
- and when A is CH2 and N1 is 1, R3 is not chlorine;
- each R4 is independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halogen, or cyano, wherein the halogen is fluorine, bromine or iodine;
- and R3 and R4 are not hydrogen at the same time;
- or when R3 is fluorine, not all of the substituents at other positions of the benzene ring are hydrogen or position 5 of the benzene ring is not fluorine;
- and
- the stereo configuration of α- or β-position carbon atom is each independently R, S or (R, S).
A compound selected from the group consisting of:
- or a tautomer, an enantiomer, a diastereomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.