Method of treatment of drug resistant hypertension
AssigneeBaroPace, Inc.
InventorsMichael Burnam, Eli Gang
Life of this patent
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Abstract
A method of right atrial pacing of a heart of a patient includes the steps of: stimulating right atrial tissue of the heart using a right atrial lead of a dual chamber cardiac pacemaker to pace the heart with a stimulus architecture protocol; and stimulating local sympathetic and/or parasympathetic tissues with the stimulus architecture protocol proximate to the paced right atrial tissue causing nervous system activity that inhibits the autonomous nervous system to reduce blood pressure. A closed loop system operating according to this method and a cardiac pacing lead for implementing this method also are included within the scope of the illustrated embodiments.
Claims15
A method for determining stimulus protocols, the method comprising:
- receiving a physiological input value;
- calculating a pacing rate based on the physiological input value;
- determining a supra-threshold stimulus protocol to produce cardiac pacing and stimulation of one or both of local sympathetic tissue or parasympathetic tissues to modify the physiological input value, based on the pacing rate;
- determining a sub-threshold stimulus protocol to produce feedback inhibition of a portion of an autonomic nervous system to modify the physiological input value, based on the pacing rate;
- determining, for each of the supra-threshold stimulus protocol and the sub-threshold stimulus protocol, a respective composite amplitude of pacing stimulus, frequency of sub-pulses, duration of sub-pulses, and refractory period between a current pacing stimulus and a subsequent pacing stimulus;
- and
- transmitting, to a pacemaker for pacing a heart, the supra-threshold stimulus protocol and the sub-threshold stimulus protocol, wherein the pacemaker is configured to pace the heart at a new pacing rate based on the supra-threshold stimulus protocol or the sub-threshold stimulus protocol and based on the respective composite amplitude of pacing stimulus, frequency of sub-pulses, duration of sub-pulses, and refractory period.
A method for determining stimulus protocols, the method comprising:
- receiving a physiological input value;
- calculating a pacing rate based on the physiological input value;
- receiving one of an indication that a paced cardiac beat is required or that a paced cardiac beat is not required;
- determining, based on receiving the indication that the paced cardiac beat is required, a supra-threshold stimulus protocol to produce cardiac pacing and stimulation of one or both of local sympathetic tissue or parasympathetic tissues to modify the physiological input value, based on the pacing rate;
- determining for the supra-threshold stimulus protocol, a first composite amplitude of pacing stimulus, a first frequency of sub-pulses, a first duration of sub-pulses, and a first refractory period between a current pacing stimulus and a subsequent pacing stimulus;
- determining, based on receiving the indication that the paced cardiac beat is not required, a sub-threshold stimulus protocol to produce feedback inhibition of a portion of an autonomic nervous system to modify the physiological input value based on the pacing rate
- determining, for the sub-threshold stimulus protocol, a second composite amplitude of pacing stimulus, a second frequency of sub-pulses, a second duration of sub-pulses, and a second refractory period between a current pacing stimulus and a subsequent pacing stimulus;
- and
- transmitting, to a pacemaker for pacing a heart, the supra-threshold stimulus protocol or the sub-threshold stimulus protocol, wherein the pacemaker is configured to pace the heart at a new pacing rate based on the supra-threshold stimulus protocol or the sub-threshold stimulus protocol.
Dependencies are inferred from the claim text.