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US 12,350,405 B2Granted
High strength biomedical materials
AssigneeAccess Vascular, Inc.
InventorsJames F. Biggins, Michael Bassett, Daniel T. Donahue
Life of this patent
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Abstract
High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.
Claims21
A hydrophilic porous article, comprising:
- a polymeric material formed by physically crosslinking at least one water soluble polymer to form the hydrophilic porous article, wherein the hydrophilic porous article comprises pores that each have a diameter of 1 μm or less,
- wherein the hydrophilic porous article has a solids content of 33% to 90% w/w at equilibrium water content (EWC) and a Young's modulus of 5-100 MPa at EWC, and wherein the hydrophilic porous article is free of covalent crosslinks between the at least one water soluble polymer that forms the hydrophilic porous article.
A method for making a hydrophilic porous article, comprising:
- with a polymeric mixture comprising at least one water soluble polymer and a solvent, the polymeric mixture having a concentration of at least 10% w/w of the at least one water soluble polymer, performing the steps of:
- heating the polymeric mixture to achieve a temperature above the melting point of the polymeric mixture,
- extruding the polymeric mixture as an article;
- and
- removing the solvent from the extruded article at a temperature above a freezing point of the solvent until the article is a porous article, with the article being a porous article that comprises the at least one water soluble polymer, and the porous article is made without covalent crosslinking agents that form covalent crosslinks between polymers extruded to make the porous article.
2 more elements
Dependencies are inferred from the claim text.