Particles for administration of active ingredients and methods of making the same

A multilayer particle, the particle comprising:

• a core comprising:
• a first active ingredient, wherein the first active ingredient is selected from the group consisting of probiotics, caffeine, Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Acmella oleracea, Helichrysum umbraculigerum, Radula marginata, kava, black truffle, Syzygium aromaticum, Rosmarinus oficinalis, basil, oregano, lavender, true cinnamon, malabathrum, Cananga odorata, Riboflavin, Theanine, Ginkgo Biloba, Bacopa, and Rhodiola Rosea Extract, or combinations thereof;
• and
• a first polymer, wherein the first polymer is selected from the group consisting of alginic acid, sodium alginate, potassium alginate, calcium alginate, agar, guar gum, xanthan gum, or combinations thereof;
• a first shell, substantially surrounding the core, the first shell comprising:
• a second active ingredient, wherein the second active ingredient is selected from the group consisting of probiotics, caffeine, hemp, cannabis, Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Acmella oleracea, Helichrysum umbraculigerum, Radula marginata, kava, black truffle, Syzygium aromaticum, Rosmarinus oficinalis, basil, oregano, lavender, true cinnamon, malabathrum, Cananga odorata, Riboflavin, Theanine, Ginkgo Biloba, Bacopa, and Rhodiola Rosea Extract, or combinations thereof;
• a second polymer, wherein the second polymer is selected from the group consisting of shellac, methyl cellulose, hydroxy propyl cellulose, hydroxypropyl-methyl cellulose, ethyl methyl cellulose, carboxy methyl cellulose, ethyl cellulose, microcrystalline cellulose, cellulose, hypro mellose, hydroxyl propyl methyl cellulose, or combinations thereof;
• a second shell, substantially surrounding the first shell, the second shell comprising:
• a third polymer, wherein the third polymer is selected from the group consisting of shellac, methyl cellulose, hydroxy propyl cellulose, hydroxypropyl-methyl cellulose, ethyl methyl cellulose, carboxy methyl cellulose, ethyl cellulose, microcrystalline cellulose, cellulose, hypro mellose, hydroxyl propyl methyl cellulose, or combinations thereof;
• and
• a plurality of emulsifying agents, wherein the plurality of emulsifying agents is selected from the group consisting of an extract of Quillaja, polysorbate 20, polysorbate 40, polysorbate 45, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 81 and polysorbate 85, polyglyceryl, gum acacia, Polyglycerol polyricinoleate, sorbitan oleate 85, sorbitan oleate 65, sorbitan oleate 83, sorbitan oleate 80, sorbitan oleate 60, sorbitan oleate 40, Xanthan gum, sorbitol, mannitol, glycerol, sodium alginate, or combinations thereof, wherein:
• the particle has a Z-average diameter less than 1 micron.

A multilayer particle, the particle comprising:

• a core comprising:
• a first active ingredient, wherein the first active ingredient is caffeine;
• and
• a first polymer, wherein the first polymer is sodium alginate;
• a first shell, substantially surrounding the core, the first shell comprising:
• a second active ingredient, wherein the second active ingredient is Bacopa;
• a second polymer, wherein the second polymer is ethyl cellulose;
• a second shell, substantially surrounding the first shell, the second shell comprising:
• a third polymer, wherein the third polymer is shellac;
• and
• an emulsifying agent, wherein the emulsifying agent is Polyglycerol polyricinoleate, wherein:
• the particle has a Z-average diameter 0.5 to 5 microns.