Back to results
US 12,350,327 B2Granted
Compositions and methods for therapeutic or vaccine delivery
AssigneeGenVivo, Inc.
InventorsJacqueline Fischer-Lougheed, Bradford H. Steele, Cecilia Roh, Robert G. Johnson
Life of this patent
Estimating the term…
Abstract
Described herein are compositions for delivering a therapeutic or vaccine. Also described herein are methods for using the compositions described herein for delivering a therapeutic or a vaccine.
Claims20
A composition comprising:
- (a) a recombinant retroviral vector comprising a murine leukemia virus (MLV) comprising (i) a first nucleic acid sequence encoding a mutant integrase and (ii) a second nucleic acid sequence encoding at least one payload selected from the group consisting of a cytokine, a thymidine kinase, and an antigen, wherein the mutant integrase comprises at least one mutation in a Mg2+ binding motif of a catalytic core domain selected from the group consisting of D125A, D184A, and E220A compared to a wild-type integrase having a sequence of SEQ ID NO:
- 1, wherein the mutant integrase has defective retroviral integration activity as compared to a recombinant retroviral vector comprising the wild-type integrase, and (b) a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.