Complex for promoting cartilage differentiation comprising cartilage cell-free crush and stem cell and use thereof

A method for improving or treating arthropathy comprising administering by injection a complex for promoting cartilage differentiation comprising stem cells or a culture thereof and a cartilage cell-free crush or a pharmaceutical composition comprising the same to a subject in need thereof,

• wherein the complex for promoting cartilage differentiation or the pharmaceutical composition is formulated for administration intraarticularly or into a joint cavity,
• wherein the arthropathy involves degeneration or damage of cartilage,
• wherein the stem cells or the culture thereof are administered without being differentiated,
• wherein the stem cells or the culture thereof are co-administered in a state not attached to the cartilage cell-free crush,
• wherein the cartilage cell-free crush is porcine cartilage powder, and
• wherein the porcine cartilage powder is provided in an injection solution,
• wherein there are no side effects while differentiating stem cells into hyaline cartilage in vivo,
• wherein the stem cells or their cultures are differentiated into chondrocytes by porcine cartilage powder after administration,
• wherein the stem cells are umbilical cord blood-derived mesenchymal stem cells, and
• wherein the pharmaceutical composition is administered in the form of an injection.