Pyridopyrimidinone derivatives for use as AXL inhibitors
AssigneeOscotec Inc.
InventorsJung-Ho Kim, Jang-Sik Choi, Hee Kyu Lee, Dong-Sik Jung, Sung-Ho Park, Yung-Geun Choi
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Abstract
Pyridopyrimidinone derivatives and pharmaceutical compositions containing the same for use as an Axl inhibitor for the treatment of a disease or condition mediated by Axl such as cancer and metastasis, are disclosed. Also disclosed are methods for treating a Axl-mediated disease or condition by administering to a subject a therapeutically effective amount of the pyridopyrimidinone derivative.
Claims5
A method of inhibiting Axl in a subject in need thereof, comprising administering an effective amount of a composition comprising 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride, or a pharmaceutically acceptable salt thereof to the subject,
- wherein the subject suffers from a disease or condition mediated by Axl;
- wherein the disease or condition is a solid tumor;
- wherein the method further comprises administering an immune checkpoint blocker;
- and
- wherein the immune checkpoint blocker is an anti-PD-1 antibody.
Dependencies are inferred from the claim text.