Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
AssigneesUniversite De Bretagne Occidentale, Centre Hospitalier RéGional Et Universitaire De Brest, Inserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsRaphaele Le Garrec, Killian L'Herondelle, Laurent Misery, Ophelie Pierre, Olivier Mignen
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Abstract
The present invention relates to the treatment of sensory neuropathy induced by a marine neurotoxic poisoning. The invention further encompasses an in vitro method for producing a neuro-cutaneous model allowing to study the cellular and/or molecular mechanisms involved in said neuropathy, a neuro-cutaneous model obtainable according to said method, and applications thereof.
Claims17
A method for treating a sensory neuropathy induced by poisoning with a marine sodium-activating neurotoxin in a subject in need thereof, said method comprising administering a therapeutically effective amount of a protease-activated receptor-2 (PAR-2) inhibitor to the subject.
Dependencies are inferred from the claim text.