# US 12,349,675 B2 · Colloidal particle formulations with advanced functionality

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- Number: US 12,349,675 B2
- Document ID: US12349675B2
- Status: Granted
- Kind: B2
- Application number: 17/247,808
- Filed: 2020-12-23
- Published: 2021-08-12
- Granted: 2025-07-08
- Earliest claimed: 2020-02-12
- Assignees: Benanova Inc.
- Applicants: Benanova Inc.
- Inventors: Anka Veleva
- Web page: https://patentgrep.com/patent/US12349675B2

## CPC

- A01N 25/22: containing ingredients stabilising the active ingredients
- A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16)
- A01N 25/10: Macromolecular compounds
- A01N 59/20: Copper
- A01P 1/00: Disinfectants; Antimicrobial compounds or mixtures thereof
- C07G 1/00: Low-molecular-weight derivatives of lignin (high-molecular-weight derivatives of lignin {C08H6/00})
- C08L 97/00: Compositions of lignin-containing materials (of polysaccharides C08L1/00 - C08L5/00)
- C08L 97/005: {Lignin}
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- C07G: COMPOUNDS OF UNKNOWN CONSTITUTION (sulfonated fats, oils or waxes of undetermined constitution C07C309/62)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

Disclosed is a method for creating a composite colloidal particle formulation with advanced functionality that possesses highly efficient and effective properties. The composite colloidal particle formulation comprises an engineered biodegradable particle core dispersed in a bioadhesive polyelectrolyte solution. Also disclosed are methods of use of the same, including but not limited to applying said formulation to plants for disease treatment.

## Claims

### Claim 1

A composite colloidal particle formulation ready for administration to treat or prevent disease in plants comprising:
a solid colloidal particle dispersed in a volume of a polyelectrolyte solution,
wherein the solid colloidal particle is plant-derived and comprises a lignin or modified hydrophobic lignin, and
wherein the volume of polyelectrolyte solution is a liquid continuous phase and comprises a chitosan, water, and ethanol,
wherein the formulation is fully biodegradable.

### Claim 2 (depends on 1)

The composite colloidal particle formulation of claim 1, wherein the solid colloidal particle comprises lignin at a concentration of at least 0.001 percent by weight.

### Claim 3 (depends on 1)

The composite colloidal particle formulation of claim 1, wherein the polyelectrolyte solution comprises chitosan at a concentration of at least 0.005 percent by weight.

### Claim 4 (depends on 1)

The composite colloidal particle formulation of claim 1, wherein the solid colloidal particle has a diameter of about 10 nm to about 500 nm.

### Claim 5 (depends on 1)

A coated article comprising a surface wherein at least a portion of the surface is coated with the composite colloidal particle system of claim 1.

### Claim 6 (depends on 1)

A method for treating or preventing disease in a plant comprising applying to the plant the composite colloidal particle formulation of claim 1.

### Claim 7 (depends on 6)

The method of treating or preventing disease in claim 6 wherein the disease is caused by a bacterial or fungal pathogen.

### Claim 8 (depends on 6)

The method of claim 6 wherein the disease is bacterial spot.

### Claim 9 (depends on 6)

The method of claim 6, wherein the plant is a member of the family Solanaceae.

### Claim 10 (depends on 6)

The method of claim 6, wherein the plant is a member of the genus Capsicum.

### Claim 11 (depends on 6)

The method of claim 6, wherein the plant is a member of the genus Lycopersicon.

### Claim 12 (depends on 1)

The composite colloidal particle formulation of claim 1, wherein the volume of polyelectrolyte solution comprises polysaccharides, polypeptides, lectins, proteins, or antibodies or materials with affinity to microbes, viruses, seeds, or plant foliage.

### Claim 13 (depends on 12)

The composite colloidal particle formulation of claim 12, wherein the polyelectrolyte solution is cationic.