US 12,345,647 B2 · Probe for detecting trace uranyl ions and portable ECL detector based on the same

Abstract

A high-sensitivity, high-selectivity and portable detection method for trace uranyl ion is described. The method has an ultralow detection limit of 11 pM/2.6 ppt and is useful in precise monitoring of the uranium content in agricultural and sideline products, foods, environments and so on. The test instrument is miniaturized and low in cost to achieve high-precision portable measurement in the field. A conjugated polymer with aggregation-induced emission (AIE) activity is synthesized, and prepared into Pdots, and a uranyl-responsive electrochemiluminescence (ECL) probe is developed by modifying the Pdots with DNA or RNA, which serves as an adsorption ligand of uranyl ion. The probe exhibits good biocompatibility. The ECL technology can be used in uranyl ion detection and the method has extremely high sensitivity. A uranyl ion probe with AIE activity is also disclosed, which can be applied in portable precise monitoring of trace uranyl ion by means of the ECL technology.

Claims10

Dependent claims

A probe for detecting trace uranyl ions, comprising conjugated polymer dots with AIE activity and a nucleotide sequence modified on the surface of the conjugated polymer dots, wherein the nucleotide sequence is a DNA and/or RNA sequence, and the conjugated polymer in the conjugated polymer dots has the structural Formula (1):

where R1 is an alkyl group, alkoxy group, substituted alkyl group or substituted alkoxy group containing 1-20 carbon atoms, in which the substituents in the substituted alkyl group and the substituted alkoxy group are independently selected from the group consisting of amino, carboxyl, hydroxyl, an ether bond, halo, a phosphoric acid group, an aldehyde group, a sulfonic acid group, a thioether bond, an ester group, amido, a Schiff base, an oximido, aryl, a sulfone group and a sulfoxide group;
and n=2-300.

Dependencies are inferred from the claim text.

Probe for detecting trace uranyl ions and portable ECL detector based on the same

Life of this patent

Probe for detecting trace uranyl ions and portable ECL detector based on the same

Life of this patent

Abstract

Claims10