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US 12,344,899 B2Granted
Compositions and methods for therapeutics prescreening
AssigneeTechnion Research & Development Foundation Limited
InventorsAvi Schroeder, Zvi Yaari
Life of this patent
Estimating the term…
Abstract
A theranostic composition and method for determining the cell-specific potency of drugs is provided. Further, compositions and methods useful for studying the therapeutic profile of one or more drugs within a cell microenvironment, including but not limited to a tumor, are provided.
Claims20
A method of determining in vivo biodistribution of a type of carrier in a subject, the method comprising:
- a. systemically administering to said subject a composition comprising a first type of carrier comprising one or more nucleic acid molecules comprising a barcode uniquely identifying said type of carrier;
- b. obtaining from said subject a sample from a plurality of tissue comprising cells;
- and
- c. identifying, in said cells the presence of said nucleic acid barcode, wherein the presence of said nucleic acid barcode indicates the in vivo biodistribution of said type of carrier to said tissue;
- wherein each of said one or more nucleic acid molecules is 500 or fewer nucleotides in length;
- thereby determining biodistribution of a type of carrier in a subject.
3 more elements
A method of determining in vivo bodily biodistribution of a type of carrier in a subject, the method comprising:
- a. systemically administering to said subject a composition comprising a first type of carrier comprising one or more nucleic acid molecules comprising a barcode uniquely identifying said type of carrier;
- b. obtaining from said subject a sample from a plurality of tissues comprising cells;
- and
- c. identifying, in said cells the presence of said nucleic acid barcode, wherein the presence of said nucleic acid barcode indicates the in vivo bodily biodistribution of said type of carrier to said tissues;
- wherein each of said one or more nucleic acid molecules is 500 or fewer nucleotides in length;
- thereby determining in vivo bodily biodistribution of a type of carrier in a subject.
3 more elements
Dependencies are inferred from the claim text.