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US 12,344,837 B2Granted
Gene-drive in DNA viruses
AssigneeBuck Institute for Research on Aging
InventorMarius Walter
Life of this patent
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Abstract
In various embodiments methods of utilizing gene drive constructs in asexual organisms such as viruses are provided. In certain embodiments the methods involve transfecting or infecting a cell with a modified DNA virus containing a gene drive construct; and infecting the cell with the target virus where the genome of said target DNA virus is modified by insertion of the gene drive construct into the genome of the target DNA virus and a population of modified target viruses (containing the gene drive construct) is produced.
Claims17
A method of modifying a target DNA virus, said method comprising:
- transfecting or infecting a cell population with a modified DNA virus containing a gene drive construct;
- and
- infecting said cell population with said target DNA virus
- wherein the genome of said target DNA virus is modified by insertion of said gene drive construct into the genome of said target DNA virus thereby producing a modified target virus,
- wherein said target DNA virus and said modified DNA virus are the same species of DNA virus.
2 more elements
Dependencies are inferred from the claim text.