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US 12,344,693 B2Granted
Lipid-polymer based complexation and delivery of nucleic acids
AssigneeUniversity of Massachusetts
InventorsSankaran Thayumanavan, Kingshuk Dutta
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Abstract
The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
Claims17
A molecular assembly, comprising:
- a crosslinked polymer-nucleic acid complex comprising a nucleic acid encapsulated in a crosslinked polymer network;
- and
- a coating on the crosslinked polymer-nucleic acid complex, wherein the coating comprises a zwitterionic lipid and a PEGylated lipid.
Dependencies are inferred from the claim text.