Synthetic polymers and crosslinked hydrogel systems
AssigneeMcMaster University
InventorsSarah Alison Stewart, Harald Donald Helmut Stover, Michael Bradley Coulson
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Abstract
A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.
Claims20
A crosslinked hydrogel comprising a first side-chain functionalized hydrophilic backbone polymer functionalized with an activated alkene, which is a vinylsulfone, acrylate, or methacrylate, or with an alkynyl group, and crosslinked with a free or protected thiol-containing compound.
Dependencies are inferred from the claim text.