Antifungal agents and uses thereof

A method of treating or preventing a fungal infection in a subject, the method comprising administering to the subject a compound described by formula (II):

• wherein,
• R2 is NH(CH2CH2O)sCH2CH2X8, NH(CH2CH2CH2O)sCH2CH2X8, NH(CH2CH2NH)tCH2CH2X9, NH[CH2(CH2)aO]bCH{CH2[OCH2(CH2)c]dX9}2, O[CH2(CH2)aO]bCH{CH2[OCH2(CH2)c]dX9}2, NHCH2(CH2)uX10, or OCH2(CH2)uX10;
• X8 is OH, ORG1, NH2, NHRG1, NRG1RG2, NRG1RG2RG3, OCH2(CH2)wZ2, or NHCH2(CH2)vZ2;
• each X9 is, independently, selected from OH, ORH1, NHRH1, NRH1RH2, NRH1RH2RH3, OCH2(CH2)wZ2, and NHCH2(CH2)vZ2;
• X10 is selected from NRI1RI2RI3 or Z2;
• a is an integer from 1 to 2;
• b is an integer from 0 to 3;
• c is an integer from 1 to 2;
• d is an integer from 0 to 3;
• s is an integer from 1 to 5;
• t is an integer from 1 to 5;
• u is an integer from 1 to 3;
• each of RG1, RG2, RG3, RH1, RH2, RH3, RI1, RI2, and RI3 is, independently, selected from CH3, CH2CH3, CH2CH2CH3, and CH(CH3)2;
• w is an integer from 1 to 3;
• Z2 is selected from
• and each of R1A, R2A, R3A, R4A, R5A, R6A, R7A, R8A, R9A, R10A, R11A, R12A, R13A, R14A, R15A, R16A, R17A, R18A, R19A, R20A, R21A, and R22A is, independently, selected from H, CH3, CH2CH3, CH2CH2CH3, and CH(CH3)2,
• or a pharmaceutically acceptable salt thereof.