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US 12,344,675 B2Granted
Polypeptide comprising a single-domain antibody variable region that binds delta-like ligand 3 (DLL3) and method of use thereof to make a radionuclide complex
AssigneeAbdera Therapeutics Inc.
InventorsMichael J. Abrams, Emma Jane Cummins, Adam Daniel Judge, Alexander Laurence Mandel, Raja Solomon Viswas
Life of this patent
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Abstract
Described herein are heavy chain antibodies that bind to DLL3 and immunoconjugates of DLL3 heavy chain antibodies useful for cancer therapy.
Claims30
A polypeptide comprising a single-domain antibody variable region that binds DLL3, wherein the single-domain antibody variable region comprises:
- a heavy chain complementarity determining region 1 (CDRH1) comprising the amino acid sequence of SEQ ID NO:
- 407, a heavy chain complementarity determining region 2 (CDRH2) comprising the amino acid sequence of SEQ ID NO:
- 410, and a heavy chain complementarity determining region 3 (CDRH3) comprising the amino acid sequence of SEQ ID NO:
- 413.
1 more element
An immunoconjugate comprising a polypeptide that binds to DLL3, wherein the polypeptide that binds to DLL3 is covalently linked to a linker-chelator moiety, or a radionuclide complex thereof, wherein:
- the polypeptide comprises a single-domain antibody variable region comprising a heavy chain complementarity determining region 1 (CDRH1) comprising the amino acid sequence of SEQ ID NO:
- 407, a heavy chain complementarity determining region 2 (CDRH2) comprising the amino acid sequence of SEQ ID NO:
- 410, and a heavy chain complementarity determining region 3 (CDRH3) comprising the amino acid sequence of SEQ ID NO:
- 413;
- and
- the linker-chelator moiety or the radionuclide complex thereof is conjugated to the polypeptide.
3 more elements
Dependencies are inferred from the claim text.