Modulators of parathyroid hormone receptor (PTHR1)
AssigneeFlagship Pioneering Innovations VI, LLC
InventorsJordi Mata-Fink, Le Phuong Ngo, Gevorg Grigoryan, Craig Owen MacKenzie, Kristen Park Hopson
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Abstract
The invention provides, inter alia, synthetic parathyroid hormones (sPTHs) that can modulate the activity of parathyroid hormone receptor, such as parathyroid hormone receptor 1 (PTHR1). The invention also provides methods of modulating PTHR activity using these sPTHs, e.g., in a cell, such as a cell in an organism.
Claims13
A polypeptide that specifically binds Parathyroid Hormone Receptor (PTHR), wherein the polypeptide comprises a synthetic parathyroid hormone (sPTH), wherein the sPTH comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 102-106 and SEQ ID NOs:
- 132-155.
Dependencies are inferred from the claim text.