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US 12,344,632 B2Granted
System and method for solution phase gap peptide synthesis
AssigneeTexas Tech University System
InventorsGuigen Li, Cole Seifert
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Abstract
Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
Claims1
A protecting group for Group Assisted Purification (GAP) peptide synthesis selected from the group consisting of:
- wherein
- wherein for 1B, 1C, and 1E, R is selected from the group consisting of:
- H, Me, and OMe;
- wherein for 1D, R is selected from the group consisting of:
- H and 2, 3, or 4 OMe, except that R is not H in every position;
- wherein for 1B and 1C, Y is selected from the group consisting of:
- O, S, and NH, except that for 1B when R=H, then Y is S;
- and
- wherein for 1C, X is selected from the group consisting of:
- S and NH,
- wherein for 1E, X is selected from the group consisting of:
- O, S, and NH, except that for 1E when R=H, X is not O.
9 more elements
Dependencies are inferred from the claim text.