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US 12,344,631 B2Granted
C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof
AssigneeReata Pharmaceuticals, Inc.
InventorsXin Jiang, Christopher F. Bender, Ha Do, Haizhou Sun, Melean Visnick
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Abstract
Disclosed herein are compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders, including those associated with inflammation and cancer.
Claims9
A compound of the formula:
- wherein:
- R1 is a monopolar-substituted alkyl(C≤3) wherein the monopolar substituent is —F;
- R2 is hydrogen or methyl;
- and
- R2′ is methyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.