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US 12,344,578 B2Granted
Salt forms of bempedoic acid and methods for using the same
AssigneeEsperion Therapeutics, Inc.
InventorsRichard Copp, Mohamed Abdelnasser, Christopher M. Cimarusti, Chengxiang Liu
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Abstract
The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.
Claims18
A crystalline form of the compound of formula (V):
- wherein the crystalline form of the compound of formula (V) is selected from the group consisting of a crystalline betaine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 6.2±0.2°, 13.5±0.2°, and 25.6±0.2°;
- a crystalline calcium salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 4.9±0.2°, 9.1±0.2°, and 19.7±0.2°;
- a crystalline calcium salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 6.0±0.2°, 6.8±0.2°, 8.5±0.2°, and 9.8±0.2°;
- a crystalline diethylamine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 9.6±0.2°, 14.1±0.2°, and 19.8±0.2°;
- a crystalline ethylenediamine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 10.8±0.2°, 16.2±0.2°, and 18.3±0.2°;
- a crystalline isonicotinamide salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 4.4±0.2°, 18.8±0.2°, 20.1±0.2°, and 24.5±0.2°;
- a crystalline potassium salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 5.7±0.2°, 7.3±0.2°, 9.6±0.2°, and 22.1±0.2°;
- a crystalline L-lysine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 4.2±0.2°, 19.1±0.2°, and 21.9±0.2°;
- a crystalline sodium salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 6.1±0.2°, 14.2±0.2°, 18.3±0.2°, and 24.5±0.2°;
- a crystalline ammonium salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 7.1±0.2°, 14.3±0.2°, and 16.0±0.2°;
- a crystalline piperazine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 6.7±0.2°, 15.7±0.2°, and 16.0±0.2°;
- and
- a crystalline tromethamine salt characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 6.6±0.2°, 18.2±0.2°, 18.6±0.2°, and 19.8±0.2°.
22 more elements
A co-crystal comprising the compound of formula (V):
- wherein the co-crystal of the compound of formula (V) is selected from the group consisting of a cocrystal of aspartame and the compound of formula (V), characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 7.6±0.2°, 17.3±0.2°, and 18.4±0.2°;
- a cocrystal of aspartame and the compound of formula (V), characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 4.4±0.2°, 10.6±0.2°, and 18.4±0.2°;
- and
- a cocrystal of palmitic acid and the compound of formula (V), characterized by an X-ray powder diffraction pattern comprising peaks at the following diffraction angles (2θ):
- 4.3±0.2°, 6.3±0.2°, 8.5±0.2°, and 17.0±0.2°.
4 more elements
Dependencies are inferred from the claim text.