Synthesis of straight-chain lepidopteran pheromones through one- or two-carbon homologation of fatty alkenes
AssigneeProvivi, Inc.
InventorsKeith M. Wampler, Choon Woo Lee, David Rozzell
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Abstract
Methods for the preparation of alkenes including insect pheromones are described. The methods include homologation reactions employing reagents such as 1,3-diesters, epoxides, cyanoacetates, and cyanide salts for elongation of starting materials and intermediates by one or two carbon atoms. The alkenes include insect pheromones useful in a number of agricultural applications.
Claims18
A method for the preparation of a C6-C18 alkene product, the method comprising contacting a C4-C17 alkene reactant with a homologation reagent under conditions sufficient to form the C6-C18 alkene product, wherein the C6-C18 alkene product comprises a 7-unsaturated alkene, an 8-unsaturated alkene, a 9-unsaturated alkene, or an 11-unsaturated alkene, wherein the C4-C17 alkene reactant is an alkenyl Grignard reagent, an alkenyl sulfonate, or an alkenyl halide, and wherein the C6-C18 alkene product is not a benzyl ether.
Dependencies are inferred from the claim text.