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US 12,343,723 B2Granted
Methods and compositions for surface functionalization of optical semiconductor-integrated biochips
AssigneeInSilixa, Inc.
InventorsAndrea Cuppoletti, Arjang Hassibi, Lei Pei, Yang Liu, Kshama Jirage, Arun Manickam
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Abstract
The present disclosure provides methods and compositions for surface functionalization of solid substrates. The compositions include functionalized silanes and nucleic acid constructs which may react to immobilize the nucleic acid constructs on the surface on the solid substrate. The disclosure also provides methods for immobilization of silanes and nucleic acid constructs on the surface of the substrate.
Claims18
A method for immobilizing a nucleic acid construct to a surface of a substrate, the method comprising:
- contacting a silane on the substrate with the nucleic acid construct and forming a 1,2,3-triazole via a strain-promoted alkyne-azide cycloaddition (SPAAC), thereby immobilizing the nucleic acid construct on the surface of the substrate,
- wherein the substrate comprises an integrated circuit.
Dependencies are inferred from the claim text.