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US 12,343,446 B2Granted
Bone repair product and methods of use thereof
AssigneeOsiris Therapeutics, Inc.
InventorsThomas E. Uveges, Jin-Qiang Kuang, Alla Danilkovitch, S. Michael Sinclair, Sandra D. Geraghty
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Abstract
Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
Claims25
A method of repairing a bone defect, the method comprising administering to the site of the bone defect a bone repair composition comprising:
- (a) cancellous bone chips comprising viable cells, wherein the cancellous bone chips are not processed with a loosening agent,
- (b) 5-20 wt. % devitalized and non-immunogenic periosteum pieces, based on the total weight of the composition, and
- (c) demineralized bone matrix (DBM) chips,
- wherein one or more growth factors comprised in the composition promote angiogenesis at the site of the bone defect.
1 more element
Dependencies are inferred from the claim text.