Dry double-sided material for adhesion of wet tissues and devices

A therapeutic agent delivery device for attachment to one or more wet tissue surfaces and for releasing one or more therapeutic agents to a target site comprising:

• (i) a dry adhesive material layer having a top surface and a bottom surface, the dry adhesive material layer comprising:
• one or more hydrophilic polymers;
• one or more amine coupling groups, and
• one or more cross linkers,
• wherein, the dry adhesive material layer is in the form of a film or tape having the top surface and the bottom surface, and wherein the dry adhesive material layer has a liquid content such that placement of one or more of the top and/or bottom surfaces of the dry adhesive material layer in contact with the one or more wet surfaces causes the dry adhesive material layer to absorb liquid from the one or more wet surfaces, swell to form temporary crosslinking between the dry adhesive material layer and the wet surface, and form covalent crosslinking between the one or more amine coupling groups and the one or more wet surfaces,
• wherein the dry adhesive material layer further comprises poly (acrylic acid) grafted with N-hydroxysuccinimide ester, and crosslinked by biodegradable gelatin methacrylate;
• and
• (ii) one or more therapeutic agent loaded patch disposed on one or more of the top surface and bottom surface of the dry adhesive material layer.