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US 12,343,403 B2Granted
Targeted ligand-payload based drug delivery for cell therapy
AssigneePurdue Research Foundation
InventorsPhilip S. Low, Madduri Srinivasarao, Boning Zhang
Life of this patent
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Abstract
A drug delivery platform providing flexible fine tune of cell therapy is disclosed herein. Particularly, an engineered fusion protein is coupled with a high affinity ligand carrying at least one payload of drug to be internalized by the transplanted cell to observe or regulate transplanted cell therapy effects.
Claims48
A drug delivery platform for cell therapy comprising:
- an engineered protein on a target cell for transplant, wherein the engineered protein is selected from the group consisting of SEQ ID NOS:
- 1 and 2;
- a small molecule ligand conjugated to a linker, wherein the small molecule ligand has intrinsic high affinity to the engineered protein;
- and
- at least one payload of drug conjugated to the linker, wherein the at least one payload of drug is associated with the target cell when the small molecule ligand binds to the engineered protein.
2 more elements
A drug delivery platform for cell therapy comprising:
- an engineered protein on a target cell for transplant, wherein the engineered protein is selected from the group consisting of SEQ ID NOS:
- 12, 13, 14, and 15;
- a small molecule ligand conjugated to a linker, wherein the small molecule ligand has intrinsic high affinity to the engineered protein;
- and
- at least one payload of drug conjugated to the linker, wherein the at least one payload of drug is associated with the target cell when the small molecule ligand binds to the engineered protein.
2 more elements
Dependencies are inferred from the claim text.