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US 12,343,386 B2Granted
Compositions for remodeling extracellular matrix and methods of use thereof
AssigneeNanoCell Ltd.
InventorsIrit Sagi, Inna Solomonov, Eldar Zehorai
Life of this patent
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Abstract
The present invention relates to a method for increasing the embryo implantation rate in a mammalian uterus, by administering to the uterus of a mammal an effective amount of an extracellular matrix remodeling enzyme, as well as to a product which includes an extracellular remodeling enzyme.
Claims10
A method of increasing rate of embryo implantation in a uterus of a mammal, the method comprising:
- a. administering in an intrauterine manner at least one extra cellular matrix (ECM) remodeling enzyme selected from the group consisting of matrix metalloproteinase (MMP)-1 and MMP-13 to the uterus of the mammal;
- and
- b. introducing at least one embryo into the uterus, wherein steps (a) and (b) are performed concurrently, thereby increasing rate of embryo implantation.
Dependencies are inferred from the claim text.