Compositions and methods for the treatment of hepatic diseases and disorders
AssigneeLabyrinth Holdings, LLC
InventorElizabeth McKenna
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Abstract
The disclosure provides oral compositions and methods of using such compositions in treating subjects infected with one or more hepatic disorders. The compositions include lysates or cell wall extracts of one or more gram positive bacteria, exhibit particular activity against hepatitis C virus (HCV), and may be useful in treating those infected with HCV as well as other hepatic diseases or disorders. Also described are methods of treating a hepatic disease or disorder by administering a therapeutically effective amount of at least one therapeutically active agent capable of upregulating or downregulating the Complement system pathway, wherein the therapeutically active agent enhances the formation of one or more convertase enzymes.
Claims19
A liquid formulation comprising:
- (a) a lysate and/or cell wall extract from a Gram-positive bacterium comprising an active ingredient that is a toll-like receptor (TLR) ligand that activates at least one or more TLRs or Nod-like receptors (NLRs), or a pharmaceutically acceptable salt thereof;
- and
- (b) a buffer;
- wherein the liquid formulation is formulated for oral or nasal delivery;
- and
- wherein the liquid formulation is formulated to provide a controlled and sustained release of the active ingredient in a therapeutically effective amount for greater than 1 minute after administration.
Dependencies are inferred from the claim text.