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US 12,343,339 B2Granted
Bisaminoquinolines and bisaminoacridines compounds and methods of their use
AssigneeThe Trustees of the University of Pennsylvania
InventorsJeffrey Winkler, Ravi K. Amaravadi
Life of this patent
Estimating the term…
Abstract
The disclosure is directed to bisaminoquinolines and bisaminoacridines as autophagy inhibitors for treating cancer and other disease states and conditions.
Claims24
A compound of formula I, II, or III:
- or a pharmaceutically acceptable salt thereof,
- wherein
- A is
- wherein X is F, Cl, or Br and R is H, C1-6alkyl, or —C(O)C1-6alkyl;
- B is
- wherein X′ is F, Cl, or Br and R′ is H, C1-6alkyl, or —C(O)C1-6alkyl;
- R1 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroaryl;
- R2 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroaryl;
- R3 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroaryl;
- R4 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroaryl;
- R5 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroaryl;
- R6 is H, C1-6alkyl, —C(O)C1-6alkyl, alkaryl, or alkheteroalkyl;
- n is 1, 2, 3, 4, or 5;
- m is 1, 2, 3, 4, or 5;
- j is 1, 2, 3, 4, or 5;
- and
- k is 1, 2, 3, 4, or 5.
14 more elements
Dependencies are inferred from the claim text.