Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury
AssigneesMeso Scale Technologies, LLC., Georgetown University, Board of Regents, The University of Texas System
InventorsJeff Debad, Joshua Gatson, Mark Burns, Arianna Biesso
Life of this patent
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Abstract
The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1β, IL-2, IL-6, IL-10, IL-22, IP-10, TNFα, TSLP, NFL, and/or NFH.
Claims16
An assay configured to determine or detect the presence or level of two or more biomarkers in a sample from a subject, wherein said two or more biomarkers comprise apolipoprotein 4 (APOE4) and glial fibrillary acidic protein (GFAP) and wherein said assay is configured to detect GFAP at a Lower Limit of Detection (LLOD) of 0.1 to 500 femtogram/mL.
A method of assessing TBI, comprising detecting APOE4 in a subject suspected of having a traumatic brain injury.
Dependencies are inferred from the claim text.