Conjugated oligonucleotide compounds, methods of making and uses thereof

A compound of Formula (I):

• wherein:
• R1 at each occurrence is independently selected from the group consisting of hydrogen, methyl, and ethyl;
• R2 is fluoro or hydroxy;
• X1 and X2 at each occurrence are independently selected from the group consisting of methylene, oxygen, and sulfur;
• m is an integer of from 1 to 6;
• n is an integer of from 1 to 10;
• q, r, s, t, v are independently integers from 0 to 4, with the proviso that:
• (i) q and r cannot both be 0 at the same time;
• and
• (ii) s, t, and v cannot all be 0 at the same time;
• Z is:
• wherein:
• Z1, Z2, Z3, and Z4 are independently at each occurrence oxygen or sulfur;
• and
• one of the bonds between P and Z2, and P and Z3, is a single bond and the other bond is a double bond;
• and
• is:
• wherein:
• A1 is hydrogen;
• a is an integer of 2 or 3;
• and
• b is an integer of 2 to 5.