Fusion protein including GIP and FGF21 and compositions thereof
AssigneeJiangnan University
InventorsShenglong Zhu, Yongquan Chen
Life of this patent
Estimating the term…
Abstract
The invention provides a fusion protein for treating metabolic diseases, and a preparation method and use thereof. The fusion protein has a general formula of R1-L-R2 or R2-L-R1, wherein R1 is FGF21 protein, an FGF21 protein analog, or a similar peptide with the biological function of FGF21 protein; R2 is GIP, mutant GIP or a similar peptide with the biological function of GIP; and L is a linker peptide. The fusion protein of the present invention is used as a therapeutic agent or a pharmaceutical composition in the treatment of diseases associated with hyperglycemia and hyperlipidemia, including diabetes, obesity, steatohepatitis or cardiovascular diseases,
Claims3
A fusion protein, having the amino acid sequence of SEQ ID NO:
- 5 or SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.