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US 12,338,244 B2Granted
Temozolomide compounds, polymers prepared therefrom, and method of treating a disease
AssigneeUniversity of Massachusetts
InventorsTodd Emrick, Matthew Skinner, Sarah M. Ward, Banishree Saha
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Abstract
A temozolomide compound according to formula (I) is described, wherein R1, L1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.
Claims10
A polymer comprising repeating units comprising temozolomide derived from a temozolomide compound, wherein the repeating units comprising temozolomide are of formula (IV):
- wherein
- R4 is independently at each occurrence a hydrogen or a C1-6 alkyl group;
- Y is independently at each occurrence —O— or —NH—;
- L3 is independently at each occurrence a divalent C1-12 alkylene group, di(C1-12) alkylene disulfide group, C1-12alkylene ester group, C6-20arylene group, or C1-20 alkylene oxide group;
- Z is independently at each occurrence a disulfide group or an amide group;
- L1 is independently at each occurrence a divalent C1-12 alkylene group, di(C1-12 alkylene) disulfide group, C1-12 alkylene ester group, C6-20 arylene group, C1-20 alkylene oxide group, or C1-12 alkylene sulfide group;
- X is independently at each occurrence —O— or —NH—;
- and
- p is independently at each occurrence 0 or 1.
6 more elements
Dependencies are inferred from the claim text.