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US 12,338,224 B2Granted
Process-scale synthesis of urolithin A
AssigneeAmazentis SA
InventorsWolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
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Abstract
Methods for preparing a salt of urolithin A and, in turn, urolithin A. Combining in an alkaline aqueous solution a copper-containing catalyst, 2-bromo-5-hydroxybenzoic acid, and resorcinol produces a salt of urolithin A. Urolithin A has been prepared by protonating a salt of the compound.
Claims19
A method of preparing a salt of urolithin A, comprising:
- combining in an alkaline aqueous solution a copper-containing catalyst, 2-bromo-5-hydroxybenzoic acid, and resorcinol, thereby forming the salt of urolithin A;
- wherein the amount of the copper-containing catalyst is at least a trace amount but no more than 0.01 molar equivalents relative to the amount of 2-bromo-5 hydroxybenzoic acid;
- the alkaline aqueous solution comprises NaOH;
- and the molar ratio of NaOH to 2-bromo-5-hydroxybenzoic acid is about 2.8:1 to about 5.1:1.
1 more element
Dependencies are inferred from the claim text.