Compounds and their uses as thyroid hormone receptor agonists
AssigneeNanjing Ruijie Pharma Co., Ltd.
InventorsJunbo Zhang, Xiaoxin Qi
Life of this patent
Estimating the term…
Abstract
A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. (I), (Ia)
Claims14
A compound of Formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof,
- Wherein:
- A is O or CH2;
- B is N or CH;
- X is O or NR1 or CHR1:
- R1 is selected from bond or H or lower alkyl;
- R2 is H or lower alkyl;
- or R1 and R2 together with the X—C═C to which they are connected form a 5- to 9-membered carbon or hetero cycle, the hetero cycle is non-substituted or substituted by R6 and R7, R6 and R7 are independently selected from the group H or lower alkyl;
- R3 and R4 are independently selected from the group consisting of H, F, Cl, Br and CH3;
- R5 is selected from the group consisting of:
Dependencies are inferred from the claim text.