Urea compound for antagonizing LPA1 receptor

A compound represented by formula [I]:

• or a pharmaceutically acceptable salt thereof, or a hydrate thereof,
• wherein
• X represents carboxy, C1-4 alkoxycarbonyl, carbamoyl, tetrazolyl, or a group selected from formula group [II]:
• W represents a structure selected from formula group [III]:
• where
• ring A1, ring A2, and ring A3 each represent C3-8 cycloalkane, a partially saturated 9- to 10-membered fused hydrocarbon aromatic ring, an oxygen atom-containing 4- to 8-membered saturated heterocycle, a sulfur atom-containing 4- to 8-membered saturated heterocycle, or a nitrogen atom-containing 4- to 8-membered saturated heterocycle,
• where
• the sulfur atom in the sulfur atom-containing 4- to 8-membered saturated heterocycle is optionally substituted with one to two oxo,
• the nitrogen atom in the nitrogen atom-containing 4- to 8-membered saturated heterocycle is optionally substituted with one group selected from the group consisting of C1-4 alkylcarbonyl and C1-4 alkoxycarbonyl, and
• RA11, RA21, and RA31 each independently represent a hydrogen atom, hydroxy, carboxy, a halogen atom, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylcarbonyl, or nitrogen atom-containing 4- to 6-membered saturated heterocyclyl(the nitrogen atom-containing 4- to 6-membered saturated heterocyclyl is optionally substituted with one C1-3 alkyl), and
• RA12, RA22, and RA32 each independently represent a hydrogen atom, a halogen atom, or methyl, or
• RA11 and RA12, RA21 and RA22, and RA31 and RA32 each optionally together form oxo, or
• RA11 and RA12, RA21 and RA22, and RA31 and RA32 each optionally form C3-6 cycloalkane together with the carbon atom(s) in the adjacent ring;
• R1 represents a hydrogen atom or methyl;
• R2 represents C6-10 alkyl, C6-10 alkenyl, C6-10 alkynyl, or a group represented by formula [IV-1] or [IV-2]:
• where
• ring B1 represents C3-8 cycloalkyl, nitrogen atom-containing 4- to 8-membered saturated heterocyclyl, phenyl, or nitrogen atom-containing 5- to 6-membered heteroaryl,
• RB11 and RB12 each independently represent a hydrogen atom, a halogen atom, C1-6 alkyl, or C1-6 alkoxy,
• L1 represents C3-8 alkanediyl(the C3-8 alkanediyl is optionally substituted with 1 to 5 fluorine atoms), a structure represented by formula [V-6]:
• —CH2CH2CH═C(CH3)—, or a structure represented by formula [V-1]:
• where
• n11 represents an integer of 0 to 3,
• n12 represents an integer of 0 to 5,
• n13 represents an integer of 0 to 3, and
• one carbon atom in the C3-8 alkanediyl, that is two or more atoms away from the nitrogen atom to which R2 is bonded, is optionally replaced with formula —O—, formula —S—, or formula —N (RL11)—, and furthermore,
• two consecutive carbon atoms in the C3-8 alkanediyl, that are one or more atoms away from the nitrogen atom to which R2 is bonded, are optionally replaced with formula —C(═O)N(RL12)—,
• RL11 represents a hydrogen atom or C1-3 alkyl, and
• RL12 represents a hydrogen atom or C1-3 alkyl,
• ring B2 represents partially saturated 9- to 10-membered fused aryl or nitrogen atom-containing 9- to 10-membered fused heteroaryl,
• RB21 and RB22 each independently represent a hydrogen atom, a halogen atom, C1-6 alkyl, or C1-6 alkoxy,
• L2 represents C1-2 alkanediyl(the C1-2 alkanediyl is optionally substituted with 1 to 4 fluorine atoms), C3-6 alkanediyl(the C3-6 alkanediyl is optionally substituted with 1 to 5 fluorine atoms), or a structure represented by formula [V-2]:
• where
• n21 represents an integer of 0 to 3,
• n22 represents an integer of 0 to 5,
• n23 represents an integer of 0 to 3, and
• one carbon atom in the C3-6 alkanediyl, that is two or more atoms away from the nitrogen atom to which R2 is bonded, is optionally replaced with formula —O—, formula —S—, or formula —N (RL21)—, and furthermore,
• two consecutive carbon atoms in the C3-6 alkanediyl, that are one or more atoms away from the nitrogen atom to which R2 is bonded, are optionally replaced with formula —C(═O)N(RL22)—,
• RL21 represents a hydrogen atom or C1-3 alkyl, and
• R122 represents a hydrogen atom or C1-3 alkyl;
• R3 represents a hydrogen atom or C1-3 alkyl(the C1-3 alkyl is optionally substituted with one group selected from the group consisting of hydroxy and methoxy);
• and
• R4 represents a group represented by formula [VI]:
• where
• ring C represents phenyl, nitrogen atom-containing 6-membered heteroaryl, or 9- to 10-membered fused heteroaryl,
• the phenyl is substituted with one group selected from the group consisting of a halogen atom, C1-6 alkyl, C1-6 alkoxy, and C1-6 alkylcarbonyl, and furthermore,
• the phenyl is optionally substituted with one to four groups that are the same or different, selected from the group consisting of hydroxy, carboxy, carbamoyl, cyano, a halogen atom, C1-6 alkyl(the C1-6 alkyl is optionally substituted with one group selected from the group consisting of hydroxy and C1-6 alkoxy), halo-C1-6 alkyl(the halo-C1-6 alkyl is optionally substituted with one hydroxy), C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl(the C3-8 cycloalkyl is optionally substituted with one hydroxy), C1-6 alkoxy, halo-C1-6 alkoxy, C3-8 cycloalkoxy, C1-6 alkylsulfanyl, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, mono-C1-6 alkylamino, di-C1-6 alkylamino, C1-6 alkylcarbonyl, halo-C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, mono-C1-6 alkylaminocarbonyl, and di-C1-6 alkylaminocarbonyl,
• the nitrogen atom-containing 6-membered heteroaryl is substituted with one C1-6 alkoxy, and furthermore,
• the nitrogen atom-containing 6-membered heteroaryl is optionally substituted with one to two groups that are the same or different, selected from the group consisting of cyano, C1-6 alkyl, C1-6 alkoxy, and oxo, and
• the 9- to 10-membered fused heteroaryl is optionally substituted with one to four groups that are the same or different, selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, and oxo;
• or
• R3 and R4, together with their adjacent carbon atom, optionally form a partially saturated 9- to 10-membered fused hydrocarbon aromatic ring or a partially saturated oxygen atom-containing 9- to 10-membered fused heteroaromatic ring,
• where
• the partially saturated 9- to 10-membered fused hydrocarbon aromatic ring is optionally substituted with one to two halogen atoms, and
• the partially saturated oxygen atom-containing 9- to 10-membered fused heteroaromatic ring is optionally substituted with one to two halogen atoms.