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US 12,337,317 B2Granted
Cell poration and transfection apparatuses
AssigneeHewlett-Packard Development Company, L.P.
InventorsAlexander Govyadinov, Viktor Shkolnikov, Diane R. Hammerstad
Life of this patent
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Abstract
In example implementations, an apparatus is provided. The apparatus includes a channel, an energy source, and a transfection chamber. The channel includes an indentation to hold a cell. The energy source is to apply a shockwave to the cell in the channel to porate the cell. The transfection chamber is to store a reagent to be inserted into the cell after the cell is porated.
Claims7
An apparatus, comprising:
- a channel comprising an indentation to hold a cell at a first wall of the channel;
- an energy source formed on a second wall of the channel to apply a shockwave to the cell in the channel to porate the cell, the energy source opposite the indentation at the first wall of the channel;
- a transfection chamber at an opening formed by the first wall and the second wall of the channel and to store a reagent to be inserted into the cell after the cell is porated;
- and
- a pump on a side of the channel opposite the transfection chamber, wherein the pump is to push the cell through the channel into the transfection chamber by pushing the cell into and out of the indentation and subsequently pushing the cell through the channel and through the opening into the transfection chamber.
2 more elements
Dependencies are inferred from the claim text.