Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
AssigneeThe Scripps Research Institute
InventorsWeijun Shen, Pengyu Yang, Huafei Zou, Peter G. Schultz
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Abstract
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
Claims9
A method for treating obesity in a human subject in need thereof, the method comprising administering to the human subject a composition comprising a peptide selected from SEQ ID NOs:
- 30-32.
A method for treating Crohn's disease, ulcerative colitis, or short bowel syndrome, in a human subject in need thereof, the method comprising administering to the human subject a composition comprising a peptide selected from SEQ ID NOs:
- 42-51.
A method for treating obesity in a human subject in need thereof, the method comprising administering to the human subject a composition comprising a peptide selected from SEQ ID NOs:
- 35-41 and 51-52.
Dependencies are inferred from the claim text.