Bacteriophage compositions
AssigneeTakeda Pharmaceutical Company Limited
InventorsMarkus Rast, Sergio Rodriguez-Morillas, Tomomine Iida
Life of this patent
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Abstract
The present invention relates to a bacteriophage composition comprising at least one bacteriophage species, at least one α-linked polymeric glucose and at least one polyol. In certain embodiments, the α-linked polymeric glucose has a mean molecular weight of greater than 10 kDa.
Claims20
A bacteriophage composition comprising:
- at least one bacteriophage species,
- at least one α-linked polymeric glucose,
- at least one polyol, wherein the polyol is sucrose or sorbitol,
- and optionally other ingredients selected from the group of buffer salts, electrolytes and surfactants, and wherein the weight ratio of the α-linked polymeric glucose to the polyol is about 4:6 to 8:2.
A method for stabilizing a bacteriophage species during spray drying, the method comprising spray drying a bacteriophage species in combination with an α-linked polymeric glucose with a mean molecular weight of from about 10 kDa to about 1000 kDa, and a polyol, wherein the polyol is sucrose or sorbitol, and wherein the weight ratio of the α-linked polymeric glucose to the polyol is about 4:6 to 8:2.
A process of preparing a dried bacteriophage composition comprising at least step 1 and step 2, involving preparing in step 1 a composition in an evaporable liquid comprising:
- at least one bacteriophage species,
- at least one α-linked polymeric glucose,
- at least one polyol, wherein the polyol is sucrose or sorbitol,
- and optionally other ingredients selected from buffer salts, electrolytes and surfactants, wherein the weight ratio of the α-linked polymeric glucose to the polyol is about 4:6 to 8:2, and
- spray drying said liquid composition from step 1 in step 2 to obtain a dry bacteriophage composition.
Dependencies are inferred from the claim text.