Back to results
US 12,337,012 B2Granted
Compositions and methods for restoring or increasing tissue perfusion
AssigneeVirginia Commonwealth University
InventorsMartin J. Mangino, Loren K. Liebrecht
Life of this patent
Estimating the term…
Abstract
A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.
Claims19
An injectable composition, comprising:
- therapeutic polyethylene glycol with a molecular weight of from 18,000 Da to 40,000 Da at a concentration of from 5% w/v to 30% w/v;
- polyethylene glycol with a molecular weight of from 1,000 Da to 10,000 Da at a concentration of from 1% w/v to 30% w/v for inhibiting erythrocyte sedimentation associated with the therapeutic polyethylene glycol;
- and
- water,
- wherein the polyethylene glycol with a molecular weight of from 18,000 Da to 40,000 Da and the polyethylene glycol with a molecular weight of from 1,000 Da to 10,000 Da are dissolved in the water to provide a total volume of the composition ranging from 100 ml to 1000 ml;
- and
- the composition is configured to be delivered by injection.
4 more elements
Dependencies are inferred from the claim text.